Search results for "Pregnenolone sulphate"
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Neurosteroid modulation of the presynaptic NMDA receptors regulating hippocampal noradrenaline release in normal rats and those exposed prenatally to…
2003
Abstract Prenatal exposure to diazepam (DZ), a positive allosteric modulator of the γ-aminobutyric acidA (GABAA) receptor complex, exerts profound effects that become more evident during puberty and in many cases are sex-specific, suggesting that such exposure interferes with the activity of steroid hormones. Apart from their well known effects on the genome, the reduced metabolites of many steroid hormones also interact directly with membrane receptors, including those for N-methyl- d -aspartate (NMDA). In this study, we compared the effects of several neurosteroids on NMDA receptors from normal rats and those exposed in utero to DZ (1.25 mg/kg per day) from the 14th through the 20th day o…
Pregnenolone sulphate (PREGS) affects spatial learning and memory in two different cognitive tasks in adult rats. Influence of the emotional state.
2009
Pregnenolone sulphate (PREGS) is one of the most potent memory-enhancing neurosteroids in rodent learning studies, also involved in the modulation of the emotional state (Valleè et al 2001). Neurosteroids exert an important role as modulators of the neuronal activity by interacting with different receptors or ion channels (Urani et al 1998). Indeed PREGS acts as negative modulator of GABAA- and as positive modulator of NMDA -receptors. Altered levels of PREGS have also been reported during aging and in human neurodegenerative pathologies like Alzheimer’s disease. The aim of this study was to investigate, in adult male rats, the effects of a single injection of PREGS (10 mg/kg s.c.) on: i) o…